› 6mdh

X-ray diffraction
1.37Å resolution

X-ray crystal structure of ISG15 from Myotis davidii

Released:
DOI: 10.2210/pdb6mdh/pdb
PDB entry 6mdh coloured by chain, front view.
PDB entry 6mdh coloured by chain, side view.
PDB entry 6mdh coloured by chain, top view.
Source organism: Myotis davidii
Primary publication:
Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement.
Langley C, Goodwin O, Dzimianski JV, Daczkowski CM, Pegan SD
Acta Crystallogr D Struct Biol 75 21-31 (2019)
PMID: 30644842

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.76 KDa
Source organism: Myotis davidii
Expression system: Escherichia coli
UniProt:
  • Canonical: L5LC70 (Residues: 1-148; Coverage: 95%)
Gene name: MDA_GLEAN10007532
Sequence domains: Ubiquitin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I212121
Unit cell:
a: 66.546Å b: 68.426Å c: 72.538Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.161 0.196
Expression system: Escherichia coli

Quick links

Citations

5 review citations

ISG15: It's Complicated.
Dzimianski et al. (2019)
4 more

1 mention without citation

Conformational Dynamics in the Interaction of SARS-CoV-2 Papain-like Protease with Human Interferon-Stimulated Gene 15 Protein.
Leite et al. (2021)