6mej

X-ray diffraction
2.8Å resolution

Crystal structure of Hepatitis C virus envelope glycoprotein E2 ectodomain in complex with human antibodies HEPC3 and HEPC46

Released:
Model geometry
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Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
PDBe Complex ID:
PDB-CPX-231607 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (7 distinct):
antibody HEPC46 Heavy Chain Chain: A
Molecule details ›
Chain: A
Length: 230 amino acids
Theoretical weight: 24.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
antibody HEPC46 Light Chain Chain: B
Molecule details ›
Chain: B
Length: 217 amino acids
Theoretical weight: 22.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
E2 glycoprotein Chain: C
antibody HEPC3 Heavy Chain Chain: H
antibody HEPC3 Light Chain Chain: L

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 86.44Å b: 76.64Å c: 118.26Å
α: 90° β: 106.33° γ: 90°
R-values:
R R work R free
0.202 0.198 0.271
Expression system: Homo sapiens