› 6mfo

X-ray diffraction
3.15Å resolution

Crystal Structure of Human Protocadherin-15 EC1-3 G16D N369D Q370N

Released:
DOI: 10.2210/pdb6mfo/pdb
Model geometry
Fit model/data
PDB entry 6mfo coloured by chain, front view.
PDB entry 6mfo coloured by chain, side view.
PDB entry 6mfo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
Choudhary D, Narui Y, Neel BL, Wimalasena LN, Klanseck CF, De-la-Torre P, Chen C, Araya-Secchi R, Tamilselvan E, Sotomayor M
OpenAccess logo Proc Natl Acad Sci U S A 117 24837-24848 (2020)
PMID: 32963095

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protocadherin-15 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 43.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96QU1 (Residues: 27-31, 32-391; Coverage: 19%)
Gene names: PCDH15, USH1F
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 5 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 87.894Å b: 116.516Å c: 99.889Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.288
Expression system: Escherichia coli BL21

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Citations

4 review citations

Mechanotransduction in mammalian sensory hair cells.
Caprara et al. (2022)
3 more