› 6mge

X-ray diffraction
2.95Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154371 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 9 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 207 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P41273 (Residues: 58-254; Coverage: 78%)
Gene name: TNFSF9
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand PO4 5 x PO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P62
Unit cell:
a: 118.91Å b: 118.91Å c: 105.494Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.197 0.194 0.246
Expression system: Trichoplusia ni

Quick links

Citations

22 review citations

Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer.
Marhelava et al. (2019)
21 more

1 mention without citation

DSP107 combines inhibition of CD47/SIRPĪ± axis with activation of 4-1BB to trigger anticancer immunity.
Cendrowicz et al. (2022)