› 6mgo

X-ray diffraction
2.2Å resolution

Structure of rabbit actin in complex with Mycalolide B

Released:
DOI: 10.2210/pdb6mgo/pdb
Model geometry
Data not analysed
Fit model/data
Data not analysed
PDB entry 6mgo coloured by chain, front view.
PDB entry 6mgo coloured by chain, side view.
PDB entry 6mgo coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix.
Pipaliya BV, Trofimova DN, Grange RL, Aeluri M, Deng X, Shah K, Craig AW, Allingham JS, Evans PA
J Am Chem Soc 143 6847-6854 (2021)
PMID: 33938740

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 377 amino acids
Theoretical weight: 42.1 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 1-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand JQV 1 x JQV
Ligand CA 1 x CA
Ligand ADP 1 x ADP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CLSI BEAMLINE 08B1-1
Spacegroup: P21
Unit cell:
a: 40.744Å b: 75.566Å c: 67.523Å
α: 90° β: 99.6° γ: 90°
R-values:
R R work R free
0.164 0.163 0.195

Quick links

Citations

1 review citation

Actin-Associated Proteins and Small Molecules Targeting the Actin Cytoskeleton.
Gao et al. (2022)
2 other articles

3 mentions without citation

Probabilistic identification of saccharide moieties in biomolecules and their protein complexes.
Dashti et al. (2020)
2 more