› 6mhs

Electron Microscopy
3.2Å resolution

Structure of the human TRPV3 channel in a putative sensitized conformation

Released:
DOI: 10.2210/pdb6mhs/pdb
PDB entry 6mhs coloured by chain, front view.
PDB entry 6mhs coloured by chain, side view.
PDB entry 6mhs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational ensemble of the human TRPV3 ion channel.
Zubcevic L, Herzik MA, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY
Nat Commun 9 4773 (2018)
PMID: 30429472
Related structures: EMD-9117

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 826 amino acids
Theoretical weight: 94.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NET8 (Residues: 2-790; Coverage: 100%)
Gene name: TRPV3
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-9117
Expression system: Spodoptera frugiperda

Quick links

Citations

15 review citations

Transient Receptor Potential Channels and Calcium Signaling.
Vangeel et al. (2019)
14 more

10 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
9 more