› 6miu

X-ray diffraction
1.9Å resolution

Crystal structure of p62 ZZ domain in complex with Arg-Glu peptide

Released:
DOI: 10.2210/pdb6miu/pdb
PDB entry 6miu coloured by chain, front view.
PDB entry 6miu coloured by chain, side view.
PDB entry 6miu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Zhang Y, Mun SR, Linares JF, Ahn J, Towers CG, Ji CH, Fitzwalter BE, Holden MR, Mi W, Shi X, Moscat J, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG
Nat Commun 9 4373 (2018)
PMID: 30349045

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sequestosome-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 57 amino acids
Theoretical weight: 6.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13501 (Residues: 115-116, 120-171; Coverage: 12%)
Gene names: ORCA, OSIL, SQSTM1
Sequence domains: Zinc finger, ZZ type

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 26.99Å b: 27.864Å c: 38.994Å
α: 90.06° β: 90.45° γ: 110.3°
R-values:
R R work R free
0.161 0.155 0.212
Expression system: Escherichia coli

Quick links

Citations

17 review citations

History of the Selective Autophagy Research: How Did It Begin and Where Does It Stand Today?
Kirkin V. (2020)
16 more

3 mentions without citation

The ZZ domain as a new epigenetic reader and a degradation signal sensor.
Zhang et al. (2019)
2 more