› 6mjh

X-ray diffraction
2.06Å resolution

The S31N mutant of the influenza A M2 proton channel in two distinct conformational states

Released:
DOI: 10.2210/pdb6mjh/pdb
PDB entry 6mjh coloured by chain, front view.
PDB entry 6mjh coloured by chain, side view.
PDB entry 6mjh coloured by chain, top view.
Source organism: Influenza A virus (A/pigeon/Jiangsu/K23/2013(H9N2))
Primary publication:
X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case.
Thomaston JL, Wu Y, Polizzi N, Liu L, Wang J, DeGrado WF
J Am Chem Soc 141 11481-11488 (2019)
PMID: 31184871

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102659 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 27 amino acids
Theoretical weight: 2.78 KDa
Source organism: Influenza A virus (A/pigeon/Jiangsu/K23/2013(H9N2))
Expression system: Not provided
UniProt:
  • Canonical: A0A0R5TVW3 (Residues: 20-44; Coverage: 28%)
Gene name: M2

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 36.29Å b: 36.15Å c: 76.45Å
α: 90° β: 103.6° γ: 90°
R-values:
R R work R free
0.22 0.217 0.248
Expression system: Not provided

Quick links

Citations

1 review citation

Antiviral Approaches against Influenza Virus.
Kumari et al. (2023)
8 other articles

3 mentions without citation

Put a cork in it: Plugging the M2 viral ion channel to sink influenza.
Jalily et al. (2020)
2 more