› 6mn6

X-ray diffraction
3.36Å resolution

Crystal structure of the cytosolic domain of human CNNM3

Released:
DOI: 10.2210/pdb6mn6/pdb
PDB entry 6mn6 coloured by chain, front view.
PDB entry 6mn6 coloured by chain, side view.
PDB entry 6mn6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter.
Chen YS, Kozlov G, Fakih R, Yang M, Zhang Z, Kovrigin EL, Gehring K
Structure 28 324-335.e4 (2020)
PMID: 31864811

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185503 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metal transporter CNNM3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 365 amino acids
Theoretical weight: 41.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q8NE01 (Residues: 299-658; Coverage: 51%)
Gene names: ACDP3, CNNM3
Sequence domains: CBS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P3221
Unit cell:
a: 128.063Å b: 128.063Å c: 111.316Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.217 0.263
Expression system: Escherichia coli BL21

Quick links

Citations

4 review citations

Ion Transporters and Osmoregulation in the Kidney of Teleost Fishes as a Function of Salinity.
Takvam et al. (2021)
3 more