› 6mp0

X-ray diffraction
2Å resolution

Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with the TRP1-M9 peptide

Released:
DOI: 10.2210/pdb6mp0/pdb
PDB entry 6mp0 coloured by chain, front view.
PDB entry 6mp0 coloured by chain, side view.
PDB entry 6mp0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses.
Clancy-Thompson E, Devlin CA, Tyler PM, Servos MM, Ali LR, Ventre KS, Bhuiyan MA, Bruck PT, Birnbaum ME, Dougan SK
Cancer Immunol Res 6 1524-1536 (2018)
PMID: 30352798

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134969 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5,6-dihydroxyindole-2-carboxylic acid oxidase; Beta-2-microglobulin; H-2 class I histocompatibility antigen, D-B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 447 amino acids
Theoretical weight: 50.05 KDa
Source organism: Mus musculus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07147 (Residues: 455-463, 493-493; Coverage: 2%)
  • Canonical: P01887 (Residues: 22-119; Coverage: 99%)
  • Canonical: P01899 (Residues: 25-300; Coverage: 82%)
Gene names: B2m, H2-D1, Tyrp-1, Tyrp1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Unit cell:
a: 50.061Å b: 98.436Å c: 121.772Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.228
Expression system: Trichoplusia ni

Quick links

Citations

1 review citation

T-cell receptor affinity in the age of cancer immunotherapy.
Hoffmann et al. (2020)
12 other articles

1 mention without citation

Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8+ T Cell-Effector Responses.
Clancy-Thompson et al. (2018)