› 6mpp

Solution NMR

HLA-A*01:01 complex with NRAS Q61K peptide by NMR

Released:
DOI: 10.2210/pdb6mpp/pdb
PDB entry 6mpp coloured by chain, ensemble of 10 models, front view.
PDB entry 6mpp coloured by chain, ensemble of 10 models, side view.
PDB entry 6mpp coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Entry authors: Flores-Solis D, McShan AC, Sgourakis NG

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-133954 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-303; Coverage: 82%)
Gene names: HLA-A, HLAA
Sequence domains:
GTPase NRas Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01111 (Residues: 55-64; Coverage: 5%)
Gene names: HRAS1, NRAS
Beta-2-microglobulin Chain: C
Molecule details ›
Chain: C
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 28%
Refinement method: distance geometry
Expression system: Escherichia coli

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