› 6mq7

X-ray diffraction
1.78Å resolution

Crystal structure of CLASP1 TOG2 domain at 1.78A resolution

Released:
DOI: 10.2210/pdb6mq7/pdb
PDB entry 6mq7 coloured by chain, front view.
PDB entry 6mq7 coloured by chain, side view.
PDB entry 6mq7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1.
Leano JB, Slep KC
PLoS One 14 e0219823 (2019)
PMID: 31323070

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182265 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CLIP-associating protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 273 amino acids
Theoretical weight: 30.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z460 (Residues: 284-552; Coverage: 18%)
Gene names: CLASP1, KIAA0622, MAST1
Sequence domains: CLASP N terminal

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 51.606Å b: 67.352Å c: 81.022Å
α: 90° β: 98.25° γ: 90°
R-values:
R R work R free
0.179 0.177 0.22
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Regulation of microtubule dynamics, mechanics and function through the growing tip.
Gudimchuk et al. (2021)
2 more

1 mention without citation

Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1.
Leano et al. (2019)