› 6mqt

X-ray diffraction
1.5Å resolution

HRAS G12S in complex with GDP

Released:
DOI: 10.2210/pdb6mqt/pdb
PDB entry 6mqt coloured by chain, front view.
PDB entry 6mqt coloured by chain, side view.
PDB entry 6mqt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bera AK, Westover KD

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133956 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase HRas, N-terminally processed Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 167 amino acids
Theoretical weight: 18.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01112 (Residues: 1-166; Coverage: 88%)
Gene names: HRAS, HRAS1
Sequence domains: Ras family

Ligands and Environments

2 bound ligands:
Ligand GDP 8 x GDP
Ligand MG 8 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 122.808Å b: 79.773Å c: 134.062Å
α: 90° β: 101.94° γ: 90°
R-values:
R R work R free
0.159 0.157 0.195
Expression system: Escherichia coli

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