› 6mqu

X-ray diffraction
3.17Å resolution

PL5, synthetic transmembrane domain variant of human phospholamban

Released:
DOI: 10.2210/pdb6mqu/pdb
PDB entry 6mqu coloured by chain, front view.
PDB entry 6mqu coloured by chain, side view.
PDB entry 6mqu coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Packing of apolar side chains enables accurate design of highly stable membrane proteins.
Mravic M, Thomaston JL, Tucker M, Solomon PE, Liu L, DeGrado WF
Science 363 1418-1423 (2019)
PMID: 30923216

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-167080 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PL5, designed TM pentamer Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 33 amino acids
Theoretical weight: 3.81 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DAR 10 x DAR

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: I41
Unit cell:
a: 124.23Å b: 124.23Å c: 51.94Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.242
Expression system: Not provided

Quick links

Citations

14 review citations

Advances in protein structure prediction and design.
Kuhlman et al. (2019)
13 more

4 mentions without citation

Protein Design: From the Aspect of Water Solubility and Stability.
Qing et al. (2022)
3 more