› 6mv7

X-ray diffraction
2.59Å resolution

Crystal structure of RNAse 6

Released:
DOI: 10.2210/pdb6mv7/pdb
PDB entry 6mv7 coloured by chain, front view.
PDB entry 6mv7 coloured by chain, side view.
PDB entry 6mv7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding.
Narayanan C, Bernard DN, Létourneau M, Gagnon J, Gagné D, Bafna K, Calmettes C, Couture JF, Agarwal PK, Doucet N
Biochemistry 59 755-765 (2020)
PMID: 31909602

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187981 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease K6 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93091 (Residues: 24-150; Coverage: 100%)
Gene names: RNASE6, RNS6
Sequence domains: Pancreatic ribonuclease

Ligands and Environments

1 bound ligand:
Ligand AMP 1 x AMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 27.65Å b: 38.83Å c: 97.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.217 0.252
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases.
Bernard et al. (2023)
1 more

2 mentions without citation

Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding.
Narayanan et al. (2020)
1 more