› 6n4x

X-ray diffraction
4Å resolution

Metabotropic Glutamate Receptor 5 Apo Form Ligand Binding Domain

Released:
DOI: 10.2210/pdb6n4x/pdb
PDB entry 6n4x coloured by chain, front view.
PDB entry 6n4x coloured by chain, side view.
PDB entry 6n4x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the activation of metabotropic glutamate receptors.
Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Nature 566 79-84 (2019)
PMID: 30675062

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 877 amino acids
Theoretical weight: 98.51 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41594 (Residues: 20-865; Coverage: 71%)
Gene names: GPRC1E, GRM5, MGLUR5
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 6 x NAG
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P2221
Unit cell:
a: 119.084Å b: 174.1Å c: 180.902Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.271 0.27 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

34 review citations

Mechanisms of adhesion G protein-coupled receptor activation.
Vizurraga et al. (2020)
33 more

4 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
3 more