› 6n5v

X-ray diffraction
2.55Å resolution

Crystal Structure of Strictosidine in complex with 1H-indole-4-ethanamine

Released:
DOI: 10.2210/pdb6n5v/pdb
PDB entry 6n5v coloured by chain, front view.
PDB entry 6n5v coloured by chain, side view.
PDB entry 6n5v coloured by chain, top view.
Source organism: Rauvolfia serpentina
Entry authors: Cai Y, Shao N, Xie H, Futamura Y, Panjikar S, Liu H, Zhu H, Osada H, Zou H

Function and Biology Details

Reaction catalysed: 
3-alpha-(S)-strictosidine + H(2)O = tryptamine + secologanin
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159353 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Strictosidine synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 316 amino acids
Theoretical weight: 35.21 KDa
Source organism: Rauvolfia serpentina
Expression system: Escherichia coli
UniProt:
  • Canonical: P68175 (Residues: 29-344; Coverage: 98%)
Gene name: STR1
Sequence domains: Strictosidine synthase

Ligands and Environments

1 bound ligand:
Ligand KDY 2 x KDY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: R3
Unit cell:
a: 150.4Å b: 150.4Å c: 122.61Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.207 0.247
Expression system: Escherichia coli

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