› 6n5z

X-ray diffraction
2.45Å resolution

Crystal structure of the SNX5 PX domain in complex with the Sema4C

Released:
DOI: 10.2210/pdb6n5z/pdb
PDB entry 6n5z coloured by chain, front view.
PDB entry 6n5z coloured by chain, side view.
PDB entry 6n5z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.
Simonetti B, Paul B, Chaudhari K, Weeratunga S, Steinberg F, Gorla M, Heesom KJ, Bashaw GJ, Collins BM, Cullen PJ
Nat Cell Biol 21 1219-1233 (2019)
PMID: 31576058

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189889 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Semaphorin-4C; Sorting nexin-5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 179 amino acids
Theoretical weight: 20.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y5X3 (Residues: 22-170; Coverage: 37%)
  • Canonical: Q9C0C4 (Residues: 731-755; Coverage: 3%)
Gene names: KIAA1739, SEMA4C, SEMAI, SNX5, UNQ5855/PRO34487
Sequence domains: PX domain

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 42.52Å b: 87.698Å c: 100.487Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.225 0.274
Expression system: Escherichia coli

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Citations

17 review citations

Phosphoinositides as membrane organizers.
Posor et al. (2022)
16 more