› 6n89

Electron Microscopy
7.5Å resolution

Cryo-EM structure of the Importin beta:Histone H1.0 complex

Released:
DOI: 10.2210/pdb6n89/pdb
PDB entry 6n89 coloured by chain, front view.
PDB entry 6n89 coloured by chain, side view.
PDB entry 6n89 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fuzzy Interactions Form and Shape the Histone Transport Complex.
Ivic N, Potocnjak M, Solis-Mezarino V, Herzog F, Bilokapic S, Halic M
Mol Cell 73 1191-1203.e6 (2019)
PMID: 30824373
Related structures: EMD-0367

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139493 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit beta-1 Chain: A
Molecule details ›
Chain: A
Length: 876 amino acids
Theoretical weight: 97.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14974 (Residues: 1-876; Coverage: 100%)
Gene names: KPNB1, NTF97
Sequence domains:
Histone H1.0 Chain: B
Molecule details ›
Chain: B
Length: 194 amino acids
Theoretical weight: 20.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07305 (Residues: 1-194; Coverage: 100%)
Gene names: H1-0, H1F0, H1FV
Sequence domains: linker histone H1 and H5 family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 7.5Å
Relevant EMDB volumes: EMD-0367
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Karyopherin-mediated nucleocytoplasmic transport.
Wing et al. (2022)
5 more

5 mentions without citation

Nuclear import of histones.
Bernardes et al. (2020)
4 more