› 6n8v

Electron Microscopy
9.3Å resolution

Hsp104DWB open conformation

Released:
DOI: 10.2210/pdb6n8v/pdb
PDB entry 6n8v coloured by chain, front view.
PDB entry 6n8v coloured by chain, side view.
PDB entry 6n8v coloured by chain, top view.
Source organism: Saccharomyces cerevisiae S288C
Primary publication:
Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Lee S, Roh SH, Lee J, Sung N, Liu J, Tsai FTF
OpenAccess logo Cell Rep 26 29-36.e3 (2019)
PMID: 30605683
Related structures: EMD-0376

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152028 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein 104 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 879 amino acids
Theoretical weight: 99.05 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P31539 (Residues: 6-884; Coverage: 97%)
Gene names: HSP104, L0948, YLL026W
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 11 x ATP
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 9.3Å
Relevant EMDB volumes: EMD-0376
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The molecular principles governing the activity and functional diversity of AAA+ proteins.
Puchades et al. (2020)
4 more

2 mentions without citation

Cryo-EM Structures of the Hsp104 Protein Disaggregase Captured in the ATP Conformation.
Lee et al. (2019)
1 more