› 6nb9

Electron crystallography
1.05Å resolution

Amyloid-Beta (20-34) with L-isoaspartate 23

Released:
DOI: 10.2210/pdb6nb9/pdb
PDB entry 6nb9 coloured by chain, front view.
PDB entry 6nb9 coloured by chain, side view.
PDB entry 6nb9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG
Nat Commun 10 3357 (2019)
PMID: 31350392
Related structures: EMD-0405

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138391 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chain: A
Molecule details ›
Chain: A
Length: 15 amino acids
Theoretical weight: 1.49 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 691-705; Coverage: 2%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand IAS 1 x IAS

Experiments and Validation Details

Entry percentile scores
Resolution: 1.05Å
Relevant EMDB volumes: EMD-0405
Expression system: Not provided

Quick links

Citations

5 review citations

Advances in methods for atomic resolution macromolecular structure determination.
Thompson et al. (2020)
4 more

1 mention without citation

Electron Diffraction of 3D Molecular Crystals.
Saha et al. (2022)