› 6ncg

X-ray diffraction
2.45Å resolution

Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to pyridin-benzenesulfonamide inhibitor

Released:
DOI: 10.2210/pdb6ncg/pdb
PDB entry 6ncg coloured by chain, front view.
PDB entry 6ncg coloured by chain, side view.
PDB entry 6ncg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: dos Reis CV, Chiodi CG, de Souza GP, Guimaraes C, Mascarello A, Gama F, Ferreira M, Counago RM, Massirer KB, Elkins JM, Arruda P, Edwards AM, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183259 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase VRK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 324 amino acids
Theoretical weight: 36.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86Y07 (Residues: 14-335; Coverage: 63%)
Gene name: VRK2
Sequence domains: Protein kinase domain
Structure domains: Transferase(Phosphotransferase) domain 1

Ligands and Environments

2 bound ligands:
Ligand KJD 2 x KJD
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 54.528Å b: 67.625Å c: 171.346Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.221 0.297
Expression system: Escherichia coli

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