› 6ncu

X-ray diffraction
3.5Å resolution

Interleukin-37 residues 53-206- dimer

Released:
DOI: 10.2210/pdb6ncu/pdb
PDB entry 6ncu coloured by chain, front view.
PDB entry 6ncu coloured by chain, side view.
PDB entry 6ncu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interleukin-37 monomer is the active form for reducing innate immunity.
Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA
Proc Natl Acad Sci U S A 116 5514-5522 (2019)
PMID: 30819901

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192742 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-37 Chains: A, B
Molecule details ›
Chains: A, B
Length: 154 amino acids
Theoretical weight: 17.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZH6 (Residues: 53-206; Coverage: 71%)
Gene names: FIL1Z, IL1F7, IL1H4, IL1RP1, IL37
Sequence domains: Interleukin-1 / 18

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3121
Unit cell:
a: 67.51Å b: 67.51Å c: 142.74Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.346 0.34 0.399
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Current Understanding of IL-37 in Human Health and Disease.
Su et al. (2021)
7 more

2 mentions without citation

Interleukin-37 monomer is the active form for reducing innate immunity.
Eisenmesser et al. (2019)
1 more