6ncv

Electron Microscopy
3.7Å resolution

Cryo-EM structure of NLRP6 PYD filament

Released:
Source organism: Homo sapiens
Primary publication:
Molecular mechanism for NLRP6 inflammasome assembly and activation.
Proc Natl Acad Sci U S A 116 2052-2057 (2019)
PMID: 30674671
Related structures: EMD-0438

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 21-mer (preferred)
PDBe Complex ID:
PDB-CPX-157745 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 6 Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, V
Length: 106 amino acids
Theoretical weight: 11.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P59044 (Residues: 1-106; Coverage: 12%)
Gene names: NALP6, NLRP6, PYPAF5
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-0438
Expression system: Spodoptera frugiperda