› 6nid

X-ray diffraction
1.86Å resolution

Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain in complex with Neurexin-1 peptide

Released:
DOI: 10.2210/pdb6nid/pdb
PDB entry 6nid coloured by chain, front view.
PDB entry 6nid coloured by chain, side view.
PDB entry 6nid coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Sun YJ, Gakhar L, Fuentes EJ

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127212 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peripheral plasma membrane protein CASK Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 88 amino acids
Theoretical weight: 10.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14936 (Residues: 485-485, 487-572; Coverage: 9%)
Gene names: CASK, LIN2
Sequence domains: PDZ domain
Neurexin-1 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 10 amino acids
Theoretical weight: 1.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9ULB1 (Residues: 1468-1477; Coverage: 1%)
Gene names: KIAA0578, NRXN1

Ligands and Environments

1 bound ligand:
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 36.328Å b: 51.177Å c: 72.412Å
α: 90° β: 97.72° γ: 90°
R-values:
R R work R free
0.194 0.192 0.24
Expression systems:
  • Escherichia coli
  • Not provided

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