› 6nle

X-ray diffraction
2.62Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130575 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+):neurotransmitter symporter (Snf family) Chain: A
Molecule details ›
Chain: A
Length: 504 amino acids
Theoretical weight: 56.45 KDa
Source organism: Aquifex aeolicus VF5
Expression system: Escherichia coli
UniProt:
  • Canonical: O67854 (Residues: 4-508; Coverage: 98%)
Gene names: aq_2077, snf
Sequence domains: Sodium:neurotransmitter symporter family

Ligands and Environments

7 bound ligands:
Ligand LEU 1 x LEU
Ligand NA 2 x NA
Ligand GOL 2 x GOL
Ligand PEG 3 x PEG
Ligand TRS 2 x TRS
Ligand BOG 1 x BOG
Ligand OCT 2 x OCT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 149.54Å b: 86.14Å c: 81.53Å
α: 90° β: 110.72° γ: 90°
R-values:
R R work R free
0.226 0.224 0.26
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Monoamine transporters: structure, intrinsic dynamics and allosteric regulation.
Cheng et al. (2019)
11 more

2 mentions without citation

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3.
Campbell et al. (2019)
1 more