› 6nrq

X-ray diffraction
1.8Å resolution

Crystal structure of Dpr10 IG1 bound to DIP-alpha IG1

Released:
DOI: 10.2210/pdb6nrq/pdb
PDB entry 6nrq coloured by chain, front view.
PDB entry 6nrq coloured by chain, side view.
PDB entry 6nrq coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.
Cheng S, Ashley J, Kurleto JD, Lobb-Rabe M, Park YJ, Carrillo RA, Özkan E
Elife 8 (2019)
PMID: 30688651

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194303 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Ig-like domain-containing protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 113 amino acids
Theoretical weight: 13.37 KDa
Source organism: Drosophila melanogaster
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9VT83 (Residues: 50-154; Coverage: 27%)
Gene names: BcDNA:RE37920, CG14158, CG14159, CG32057, CT33762, Dmel\CG32057, Dmel_CG32057, Dpr-10, Dpr10, dpr10
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: B, D
Molecule details ›
Chains: B, D
Length: 113 amino acids
Theoretical weight: 12.82 KDa
Source organism: Drosophila melanogaster
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9W4R3 (Residues: 39-143; Coverage: 20%)
Gene names: 32791, CG13019, CG13020, CG32791, DIP-alpha, Dmel\CG32791, Dmel_CG32791
Sequence domains: Immunoglobulin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand GOL 3 x GOL
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P1
Unit cell:
a: 51.011Å b: 53.551Å c: 56.685Å
α: 119.68° β: 103.77° γ: 92.88°
R-values:
R R work R free
0.176 0.174 0.205
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

Adhesion Protein Structure, Molecular Affinities, and Principles of Cell-Cell Recognition.
Honig et al. (2020)
4 more

3 mentions without citation

DIP/Dpr interactions and the evolutionary design of specificity in protein families.
Sergeeva et al. (2020)
2 more