Function and Biology Details
Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- HEAT, type 2
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- Protein phosphatase 2A, regulatory B subunit, B56
- Metallo-dependent phosphatase-like
- Armadillo-type fold
- Armadillo-like helical
- Calcineurin-like phosphoesterase domain, ApaH type
- Serine/Threonine protein phosphatase PP2A-like
1 more domain
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151665 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Molecule details ›
Chain: A
Length: 589 amino acids
Theoretical weight: 65.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: HEAT repeat
Length: 589 amino acids
Theoretical weight: 65.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P30153 (Residues: 1-589; Coverage: 100%)
Sequence domains: HEAT repeat
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Molecule details ›
Chain: B
Length: 486 amino acids
Theoretical weight: 56.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein phosphatase 2A regulatory B subunit (B56 family)
Length: 486 amino acids
Theoretical weight: 56.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q15172 (Residues: 1-486; Coverage: 100%)
Sequence domains: Protein phosphatase 2A regulatory B subunit (B56 family)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Molecule details ›
Chain: C
Length: 304 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Length: 304 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: P67775 (Residues: 1-301; Coverage: 97%)
Sequence domains: Calcineurin-like phosphoesterase
