› 6nty

X-ray diffraction
2.1Å resolution

2.1 A resolution structure of the Musashi-2 (Msi2) RNA recognition motif 1 (RRM1) domain

Released:
DOI: 10.2210/pdb6nty/pdb
PDB entry 6nty coloured by chain, front view.
PDB entry 6nty coloured by chain, side view.
PDB entry 6nty coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.
Lan L, Xing M, Kashipathy M, Douglas J, Gao P, Battaile K, Hanzlik R, Lovell S, Xu L
Proteins 88 573-583 (2020)
PMID: 31603583

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188438 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding protein Musashi homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 94 amino acids
Theoretical weight: 10.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96DH6 (Residues: 21-111; Coverage: 28%)
Gene name: MSI2
Sequence domains: RNA recognition motif

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 30.795Å b: 57.37Å c: 41.315Å
α: 90° β: 101.32° γ: 90°
R-values:
R R work R free
0.21 0.205 0.28
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

RNA-Targeted Therapies and High-Throughput Screening Methods.
Zhu et al. (2020)
1 more

2 mentions without citation

The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance.
Sicking et al. (2023)
1 more