› 6nz0

Electron Microscopy
2.4Å resolution

Cryo-EM structure of AAV-2 in complex with AAVR PKD domains 1 and 2

Released:
DOI: 10.2210/pdb6nz0/pdb
PDB entry 6nz0 coloured by chain, front view.
PDB entry 6nz0 coloured by chain, side view.
PDB entry 6nz0 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR.
Meyer NL, Hu G, Davulcu O, Xie Q, Noble AJ, Yoshioka C, Gingerich DS, Trzynka A, David L, Stagg SM, Chapman MS
Elife 8 (2019)
PMID: 31115336
Related structures: EMD-0553

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero 120-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136599 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dyslexia-associated protein KIAA0319-like protein Chain: Z
Molecule details ›
Chain: Z
Length: 290 amino acids
Theoretical weight: 31.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZA0 (Residues: 311-597; Coverage: 27%)
Gene names: AAVR, KIAA0319L, KIAA1837, PP791
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 735 amino acids
Theoretical weight: 82.08 KDa
Source organism: Adeno-associated virus 2 Srivastava/1982
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P03135 (Residues: 1-735; Coverage: 100%)
Gene name: VP1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.4Å
Relevant EMDB volumes: EMD-0553
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda

Quick links

Citations

9 review citations

Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry.
Large et al. (2021)
8 more

8 mentions without citation

Cryo-electron Microscopy of Adeno-associated Virus.
Stagg et al. (2022)
7 more