› 6nzn

Solid-state NMR

Dimer-of-dimer amyloid fibril structure of glucagon

Released:
DOI: 10.2210/pdb6nzn/pdb
PDB entry 6nzn coloured by chain, ensemble of 10 models, front view.
PDB entry 6nzn coloured by chain, ensemble of 10 models, side view.
PDB entry 6nzn coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The peptide hormone glucagon forms amyloid fibrils with two coexisting β-strand conformations.
Gelenter MD, Smith KJ, Liao SY, Mandala VS, Dregni AJ, Lamm MS, Tian Y, Xu W, Pochan DJ, Tucker TJ, Su Y, Hong M
Nat Struct Mol Biol 26 592-598 (2019)
PMID: 31235909

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134164 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucagon Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 29 amino acids
Theoretical weight: 3.49 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01275 (Residues: 53-81; Coverage: 18%)
Gene name: GCG
Sequence domains: Peptide hormone

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 6%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

4 review citations

The expanding amyloid family: Structure, stability, function, and pathogenesis.
Sawaya et al. (2021)
3 more

4 mentions without citation

From Angstroms to Nanometers: Measuring Interatomic Distances by Solid-State NMR.
Shcherbakov et al. (2022)
3 more