› 6nzz

Electron Microscopy
3.32Å resolution

LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state

Released:
DOI: 10.2210/pdb6nzz/pdb
PDB entry 6nzz coloured by chain, front view.
PDB entry 6nzz coloured by chain, side view.
PDB entry 6nzz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Kern DM, Oh S, Hite RK, Brohawn SG
OpenAccess logo Elife 8 (2019)
PMID: 30775971
Related structures: EMD-0563

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Volume-regulated anion channel subunit LRRC8A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 820 amino acids
Theoretical weight: 95.31 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q80WG5 (Residues: 1-810; Coverage: 100%)
Gene names: Lrrc8, Lrrc8a, Swell1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand POV 18 x POV
Ligand L9Y 1 x L9Y
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.32Å
Relevant EMDB volumes: EMD-0563
Expression system: Spodoptera frugiperda

Quick links

Citations

19 review citations

Biophysics and Structure-Function Relationships of LRRC8-Formed Volume-Regulated Anion Channels.
König et al. (2019)
18 more

5 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
4 more