› 6o1e

X-ray diffraction
2.41Å resolution

The crystal structure of human MORC3 ATPase-CW in complex with AMPPNP

Released:
DOI: 10.2210/pdb6o1e/pdb
PDB entry 6o1e coloured by chain, front view.
PDB entry 6o1e coloured by chain, side view.
PDB entry 6o1e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanism for autoinhibition and activation of the MORC3 ATPase.
Zhang Y, Klein BJ, Cox KL, Bertulat B, Tencer AH, Holden MR, Wright GM, Black J, Cardoso MC, Poirier MG, Kutateladze TG
Proc Natl Acad Sci U S A 116 6111-6119 (2019)
PMID: 30850548

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171942 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MORC family CW-type zinc finger protein 3 Chain: A
Molecule details ›
Chain: A
Length: 455 amino acids
Theoretical weight: 52.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14149 (Residues: 1-455; Coverage: 49%)
Gene names: KIAA0136, MORC3, NXP2, ZCWCC3
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand MG 1 x MG
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P3121
Unit cell:
a: 119.51Å b: 119.51Å c: 76.88Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.181 0.179 0.232
Expression system: Escherichia coli

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Citations

5 review citations

The Fate of Speckled Protein 100 (Sp100) During Herpesviruses Infection.
Collados Rodríguez M. (2020)
4 more

2 mentions without citation

Mechanism for autoinhibition and activation of the MORC3 ATPase.
Zhang et al. (2019)
1 more