6o6a

Electron Microscopy
3.6Å resolution

Structure of the TRPM8 cold receptor by single particle electron cryo-microscopy, ligand-free state

Released:
Source organism: Parus major
Primary publication:
Structural insights into TRPM8 inhibition and desensitization.
Science 365 1434-1440 (2019)
PMID: 31488702
Related structures: EMD-0631

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
PDBe Complex ID:
PDB-CPX-167182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 8 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1098 amino acids
Theoretical weight: 126.99 KDa
Source organism: Parus major
Expression system: Homo sapiens

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-0631
Expression system: Homo sapiens