6o7g

Solution NMR

Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide

Released:

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-127057 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone-lysine N-methyltransferase 2D Chain: B
Molecule details ›
Chain: B
Length: 64 amino acids
Theoretical weight: 7.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14686 (Residues: 1503-1562; Coverage: 1%)
Gene names: ALR, KMT2D, MLL2, MLL4
Histone H4 Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided