› 6ob6

X-ray diffraction
2.9Å resolution

Human equilibrative nucleoside transporter-1, S-(4-nitrobenzyl)-6-thioinosine bound, merohedrally twinned

Released:
DOI: 10.2210/pdb6ob6/pdb
PDB entry 6ob6 coloured by chain, front view.
PDB entry 6ob6 coloured by chain, side view.
PDB entry 6ob6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human ENT1 in complex with adenosine reuptake inhibitors.
Wright NJ, Lee SY
Nat Struct Mol Biol 26 599-606 (2019)
PMID: 31235912

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Equilibrative nucleoside transporter 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 442 amino acids
Theoretical weight: 48.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99808 (Residues: 2-456; Coverage: 93%)
Gene names: ENT1, SLC29A1
Sequence domains: Nucleoside transporter

Ligands and Environments

1 bound ligand:
Ligand NBM 2 x NBM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P61
Unit cell:
a: 72.532Å b: 72.532Å c: 335.458Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.205 0.252
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Adenosine Receptor Profiling Reveals an Association between the Presence of Spare Receptors and Cardiovascular Disorders.
Fenouillet et al. (2019)
6 more

13 mentions without citation

Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.
Wright et al. (2021)
12 more