› 6ob7

X-ray diffraction
2.3Å resolution

Human equilibrative nucleoside transporter-1, dilazep bound

Released:
DOI: 10.2210/pdb6ob7/pdb
PDB entry 6ob7 coloured by chain, front view.
PDB entry 6ob7 coloured by chain, side view.
PDB entry 6ob7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human ENT1 in complex with adenosine reuptake inhibitors.
Wright NJ, Lee SY
Nat Struct Mol Biol 26 599-606 (2019)
PMID: 31235912

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Equilibrative nucleoside transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 442 amino acids
Theoretical weight: 48.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99808 (Residues: 2-456; Coverage: 93%)
Gene names: ENT1, SLC29A1
Sequence domains: Nucleoside transporter

Ligands and Environments

2 bound ligands:
Ligand OLC 18 x OLC
Ligand 8DZ 1 x 8DZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P3221
Unit cell:
a: 72.04Å b: 72.04Å c: 173.371Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.203 0.243
Expression system: Homo sapiens

Quick links

Citations

9 review citations

Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy.
Walter et al. (2022)
8 more

13 mentions without citation

Toward a Molecular Basis of Cellular Nucleoside Transport in Humans.
Wright et al. (2021)
12 more