› 6ock

X-ray diffraction
1.9Å resolution

Crystal Structure of Leporine Serum Albumin in Complex with Ketoprofen

Released:
DOI: 10.2210/pdb6ock/pdb
PDB entry 6ock coloured by chain, front view.
PDB entry 6ock coloured by chain, side view.
PDB entry 6ock coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural investigations of stereoselective profen binding by equine and leporine serum albumins.
Zielinski K, Sekula B, Bujacz A, Szymczak I
Chirality 32 334-344 (2020)
PMID: 31905261

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155859 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 584 amino acids
Theoretical weight: 66.17 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P49065 (Residues: 25-608; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family

Ligands and Environments

5 bound ligands:
Ligand 9KL 2 x 9KL
Ligand ACT 5 x ACT
Ligand PGE 1 x PGE
Ligand POG 1 x POG
Ligand 2J3 2 x 2J3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P212121
Unit cell:
a: 73.69Å b: 79.48Å c: 103.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.253

Quick links

Citations

2 review citations

Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods.
Coelho et al. (2021)
1 more

4 mentions without citation

Albumins represent highly cross-reactive animal allergens.
Liu et al. (2023)
3 more