› 6ofp

X-ray diffraction
2.01Å resolution

Structure of the C-terminal cargo binding domain of human Bicaudal D2

Released:
DOI: 10.2210/pdb6ofp/pdb
PDB entry 6ofp coloured by chain, front view.
PDB entry 6ofp coloured by chain, side view.
PDB entry 6ofp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding.
Noell CR, Loh JY, Debler EW, Loftus KM, Cui H, Russ BB, Zhang K, Goyal P, Solmaz SR
J Phys Chem Lett 10 4362-4367 (2019)
PMID: 31306018

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein bicaudal D homolog 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 94 amino acids
Theoretical weight: 10.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TD16 (Residues: 715-804; Coverage: 11%)
Gene names: BICD2, KIAA0699

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 73.694Å b: 36.958Å c: 78.706Å
α: 90° β: 107.41° γ: 90°
R-values:
R R work R free
0.229 0.226 0.257
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Generation of Dynein Networks by Multi-Layered Regulation and Their Implication in Cell Division.
Torisawa et al. (2020)
7 other articles

3 mentions without citation

Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding.
Noell et al. (2019)
2 more