› 6oil

X-ray diffraction
1.85Å resolution

Crystal structure of human VISTA extracellular domain

Released:
DOI: 10.2210/pdb6oil/pdb
PDB entry 6oil coloured by chain, front view.
PDB entry 6oil coloured by chain, side view.
PDB entry 6oil coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and Functional Binding Epitope of V-domain Ig Suppressor of T Cell Activation.
Mehta N, Maddineni S, Mathews II, Andres Parra Sperberg R, Huang PS, Cochran JR
Cell Rep 28 2509-2516.e5 (2019)
PMID: 31484064

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190664 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
V-type immunoglobulin domain-containing suppressor of T-cell activation Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 19.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H7M9 (Residues: 33-194; Coverage: 58%)
Gene names: C10orf54, PP2135, SISP1, UNQ730/PRO1412, VISTA, VSIR
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 29.169Å b: 64.089Å c: 37.695Å
α: 90° β: 91.73° γ: 90°
R-values:
R R work R free
0.182 0.18 0.223
Expression system: Homo sapiens

Quick links

Citations

28 review citations

Revisiting Immunotherapy: A Focus on Prostate Cancer.
Cha et al. (2020)
27 more

8 mentions without citation

VISTA inhibitors in cancer immunotherapy: a short perspective on recent progresses.
Wu et al. (2021)
7 more