› 6oov

X-ray diffraction
2.2Å resolution

Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA

Released:
DOI: 10.2210/pdb6oov/pdb
PDB entry 6oov coloured by chain, front view.
PDB entry 6oov coloured by chain, side view.
PDB entry 6oov coloured by chain, top view.
Source organisms:
Entry authors: Halabelian L, Zeng H, Li Y, Bountra C, Edwards AM, Arrowsmith CH, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120398 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Abasic site processing protein HMCES Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 31.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96FZ2 (Residues: 2-270; Coverage: 76%)
Gene names: C3orf37, DC12, HMCES, SRAPD1
Sequence domains: SOS response associated peptidase (SRAP)
Structure domains: SOS response associated peptidase-like
DNA (5'-D(*CP*AP*AP*CP*GP*TP*TP*GP*TP*TP*TP*TP*T)-3') Chains: C, D
Molecule details ›
Chains: C, D
Length: 13 nucleotides
Theoretical weight: 3.95 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand UNX 47 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 45.729Å b: 139.828Å c: 66.613Å
α: 90° β: 99.99° γ: 90°
R-values:
R R work R free
0.195 0.194 0.219
Expression systems:
  • Escherichia coli
  • Not provided

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