› 6or2

X-ray diffraction
2.59Å resolution

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

Released:
DOI: 10.2210/pdb6or2/pdb
PDB entry 6or2 coloured by chain, front view.
PDB entry 6or2 coloured by chain, side view.
PDB entry 6or2 coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine.
Su CC, Klenotic PA, Bolla JR, Purdy GE, Robinson CV, Yu EW
Proc Natl Acad Sci U S A 116 11241-11246 (2019)
PMID: 31113875

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trehalose monomycolate exporter MmpL3 Chain: A
Molecule details ›
Chain: A
Length: 779 amino acids
Theoretical weight: 85.44 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli
UniProt:
  • Canonical: A0QP27 (Residues: 1-773; Coverage: 76%)
Gene names: MSMEG_0250, MSMEI_0243, mmpL3
Sequence domains: MMPL family

Ligands and Environments

2 bound ligands:
Ligand L9Q 1 x L9Q
Ligand LMT 1 x LMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 80.814Å b: 129.457Å c: 154.591Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.249 0.29
Expression system: Escherichia coli

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Citations

18 review citations

Underestimated Manipulative Roles of Mycobacterium tuberculosis Cell Envelope Glycolipids During Infection.
Garcia-Vilanova et al. (2019)
17 more

11 mentions without citation

Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.
Alav et al. (2021)
10 more