› 6owv

X-ray diffraction
1.88Å resolution

Crystal structure of a Human Cardiac Calsequestrin Filament

Released:
DOI: 10.2210/pdb6owv/pdb
PDB entry 6owv coloured by chain, front view.
PDB entry 6owv coloured by chain, side view.
PDB entry 6owv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.
Titus EW, Deiter FH, Shi C, Wojciak J, Scheinman M, Jura N, Deo RC
Nat Struct Mol Biol 27 1142-1151 (2020)
PMID: 33046906

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calsequestrin-2 Chain: A
Molecule details ›
Chain: A
Length: 387 amino acids
Theoretical weight: 44.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14958 (Residues: 18-399; Coverage: 100%)
Gene name: CASQ2
Sequence domains: Calsequestrin

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand CL 25 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P4322
Unit cell:
a: 62.533Å b: 62.533Å c: 213.189Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.213 0.249
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia.
Wleklinski et al. (2020)
3 more

3 mentions without citation

Functions and mechanisms of protein disulfide isomerase family in cancer emergence.
Rahman et al. (2022)
2 more