› 6oy3

Electron Microscopy
4Å resolution

nhTMEM16 L302A +Ca2+ in nanodiscs

Released:
DOI: 10.2210/pdb6oy3/pdb
PDB entry 6oy3 coloured by chain, front view.
PDB entry 6oy3 coloured by chain, side view.
PDB entry 6oy3 coloured by chain, top view.
Source organism: Fusarium vanettenii 77-13-4
Primary publication:
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16.
Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H
Nat Commun 10 4972 (2019)
PMID: 31672969
Related structures: EMD-20221

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasma membrane channel protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 735 amino acids
Theoretical weight: 83.16 KDa
Source organism: Fusarium vanettenii 77-13-4
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: C7Z7K1 (Residues: 1-735; Coverage: 100%)
Gene name: NECHADRAFT_66456
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-20221
Expression system: Saccharomyces cerevisiae

Quick links

Citations

2 review citations

Phospholipid Scrambling by G Protein-Coupled Receptors.
Khelashvili et al. (2022)
1 more

2 mentions without citation

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16.
Khelashvili et al. (2019)
1 more