› 6p4e

X-ray diffraction
1.35Å resolution

Leishmania mexicana CPB in complex with an aza-nitrile inhibitor

Released:
DOI: 10.2210/pdb6p4e/pdb
Model geometry
Fit model/data
PDB entry 6p4e coloured by chain, front view.
PDB entry 6p4e coloured by chain, side view.
PDB entry 6p4e coloured by chain, top view.
Source organism: Leishmania mexicana
Entry authors: Ribeiro JFR, Li C, De Vita D, Emsley J, Montanari CA

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cysteine proteinase B Chains: A, B
Molecule details ›
Chains: A, B
Length: 217 amino acids
Theoretical weight: 23.21 KDa
Source organism: Leishmania mexicana
Expression system: Escherichia coli
UniProt:
  • Canonical: P36400 (Residues: 125-341; Coverage: 52%)
Gene names: LMCPB, LMCPB2.8
Sequence domains: Papain family cysteine protease

Ligands and Environments

5 bound ligands:
Ligand NA 2 x NA
Ligand ACT 6 x ACT
Ligand MPD 2 x MPD
Ligand GES 2 x GES
Ligand TRS 1 x TRS
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I23
Spacegroup: P63
Unit cell:
a: 82.636Å b: 82.636Å c: 134.846Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.19 0.213
Expression system: Escherichia coli

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