› 6p6b

Solution NMR

CS-Rosetta Model of PEA-15 Death Effector Domain

Released:
DOI: 10.2210/pdb6p6b/pdb
PDB entry 6p6b coloured by chain, ensemble of 10 models, front view.
PDB entry 6p6b coloured by chain, ensemble of 10 models, side view.
PDB entry 6p6b coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions.
Crespo-Flores SL, Cabezas A, Hassan S, Wei Y
Int J Mol Sci 20 (2019)
PMID: 31284641

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172223 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Astrocytic phosphoprotein PEA-15 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15121 (Residues: 1-90; Coverage: 69%)
Gene name: PEA15
Sequence domains: Death effector domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 36%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

Phosphorylation of PED/PEA-15 at Ser116 and phosphorylation of p27 at Thr187 indicates a poor prognosis in hepatocellular carcinoma.
Wu et al. (2021)
1 more

2 mentions without citation

Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond.
Ha et al. (2020)
1 more