› 6p6w

Electron Microscopy
4Å resolution

Cryo-EM structure of voltage-gated sodium channel NavAb N49K/L109A/M116V/G94C/Q150C disulfide crosslinked mutant in the resting state

Released:
DOI: 10.2210/pdb6p6w/pdb
PDB entry 6p6w coloured by chain, front view.
PDB entry 6p6w coloured by chain, side view.
PDB entry 6p6w coloured by chain, top view.
Source organisms:
Primary publication:
Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Wisedchaisri G, Tonggu L, McCord E, Gamal El-Din TM, Wang L, Zheng N, Catterall WA
Cell 178 993-1003.e12 (2019)
PMID: 31353218
Related structures: EMD-20265

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein; Maltose/maltodextrin-binding periplasmic protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 661 amino acids
Theoretical weight: 74.07 KDa
Source organisms: Expression system: Trichoplusia ni
UniProt:
  • Canonical: P0AEX9 (Residues: 1-392; Coverage: 99%)
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene names: Abu_1752, JW3994, b4034, malE
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-20265
Expression system: Trichoplusia ni

Quick links

Citations

19 review citations

Sodium channelopathies of skeletal muscle and brain.
Mantegazza et al. (2021)
18 more

17 mentions without citation

De novo CACNA1D Ca2+ channelopathies: clinical phenotypes and molecular mechanism.
Ortner et al. (2020)
16 more