› 6p6y

X-ray diffraction
2.89Å resolution

Crystal structure of voltage-gated sodium channel NavAb V100C/Q150C disulfide crosslinked mutant in the activated state

Released:
DOI: 10.2210/pdb6p6y/pdb
Model geometry
Data not analysed
Fit model/data
Data not analysed
PDB entry 6p6y coloured by chain, front view.
PDB entry 6p6y coloured by chain, side view.
PDB entry 6p6y coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Wisedchaisri G, Tonggu L, McCord E, Gamal El-Din TM, Wang L, Zheng N, Catterall WA
Cell 178 993-1003.e12 (2019)
PMID: 31353218

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 29.77 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-239; Coverage: 90%)
Gene name: Abu_1752
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand CPS 2 x CPS
Ligand PX4 5 x PX4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I422
Unit cell:
a: 125.83Å b: 125.83Å c: 189.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.214 0.273
Expression system: Trichoplusia ni

Quick links

Citations

22 review citations

Sodium channelopathies of skeletal muscle and brain.
Mantegazza et al. (2021)
21 more

4 mentions without citation

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel.
Wisedchaisri et al. (2019)
3 more