› 6pbf

Electron Microscopy
4.2Å resolution

ZINC9155420-bound TRPV5 in nanodiscs

Released:
DOI: 10.2210/pdb6pbf/pdb
PDB entry 6pbf coloured by chain, front view.
PDB entry 6pbf coloured by chain, side view.
PDB entry 6pbf coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structure-based characterization of novel TRPV5 inhibitors.
Hughes TE, Del Rosario JS, Kapoor A, Yazici AT, Yudin Y, Fluck EC, Filizola M, Rohacs T, Moiseenkova-Bell VY
Elife 8 (2019)
PMID: 31647410
Related structures: EMD-20292

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 730 amino acids
Theoretical weight: 82.9 KDa
Source organism: Oryctolagus cuniculus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9XSM3 (Residues: 1-730; Coverage: 100%)
Gene names: Ecac1, Trpv5
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand O6V 4 x O6V
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-20292
Expression system: Saccharomyces cerevisiae

Quick links

Citations

11 review citations

Structural mechanisms of transient receptor potential ion channels.
Cao E. (2020)
10 more

3 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
2 more