› 6pbh

X-ray diffraction
1.89Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137829 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 32.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P04439 (Residues: 25-302; Coverage: 82%)
Gene names: HLA-A, HLAA
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Nucleoprotein Chain: C
Molecule details ›
Chain: C
Length: 12 amino acids
Theoretical weight: 1.45 KDa
Source organism: unidentified influenza virus
Expression system: Not provided
UniProt:
  • Canonical: Q9Q0U8 (Residues: 145-156; Coverage: 2%)
Gene name: NP

Ligands and Environments

3 bound ligands:
Ligand IOD 1 x IOD
Ligand MG 3 x MG
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 59.75Å b: 79.004Å c: 112.651Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.234
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

2 review citations

The ABC of Major Histocompatibility Complexes and T Cell Receptors in Health and Disease.
Kedzierska et al. (2020)
1 more

8 mentions without citation

Epitope based vaccine prediction for SARS-COV-2 by deploying immuno-informatics approach.
Joshi et al. (2020)
7 more